Cognitive impairment is associated with elevated oxygen extraction and metabolism in the medial temporal lobe
Motivation: Currently, the primary MRI-based biomarker for cognitive dysfunction is the atrophy of medial-temporal-lobe (MTL). However, MTL atrophy represents a late stage of tissue damage. Functional biomarkers such as the MTL oxygen metabolism may be more sensitive in early stages. Goal(s): To evaluate the association of MTL oxygen metabolism with cognitive function in non-demented elderly individuals. Approach: We used a novel MRI technique to evaluate the MTL oxygen metabolism in 48 elderly subjects. Cognitive function of the participants was assessed. Results: Worse cognitive scores were associated with elevated oxygen extraction and metabolic rate in the MTL, but not with the volume of MTL. Impact: Our findings indicated that measuring the oxygen extraction and metabolic rate in the medial temporal lobe may be more sensitive than structural atrophy in detecting tissue damage in early stages of cognitive impairment.
Authors
- Kaisha Hazel (ORCID: https://orcid.org/0000-0003-0078-3714)
- Dengrong Jiang (ORCID: https://orcid.org/0000-0002-3843-1020)
- Sevil Yaşar (ORCID: https://orcid.org/0000-0002-5080-6534)
- Hanzhang Lu (ORCID: https://orcid.org/0000-0003-3871-1564)
- Doris D M Lin (ORCID: https://orcid.org/0000-0002-6001-2383)
- Rita Rastogi Kalyani (ORCID: https://orcid.org/0000-0002-1530-6884)
- Cuimei Xu
- Abhay Moghekar (ORCID: https://orcid.org/0000-0001-9464-1551)
- Paul B. Rosenberg (ORCID: https://orcid.org/0000-0003-1106-4299)
- Wen Shi (ORCID: https://orcid.org/0000-0002-6624-2331)
- George Pottanat (ORCID: https://orcid.org/0000-0002-3908-7663)
- Jie Song (ORCID: https://orcid.org/0000-0003-1144-1971)
- Ebony Jones
- Julia Suconic
- Marilyn Albert
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3887
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00