A MULTIPLEX-Lite method for fast 3D multi-parametric imaging with MR Angiography

Motivation: Existing 3D multi-parametric imaging methods suffers from long scan times, and decent MRA contrasts are yet to be provided. Goal(s): To develop a 3-minute 3D high resolution multi-parametric imaging method that offeres whole brain imaging with TOF quality MRA results. Approach: A simplified version of the MULTIPLEX method, namely MULTIPLEX-Lite, is proposed. Compared to the original MULTIPLEX method, addtional MRA results are offered, while removing the T1 and PD mappings to further improve scan time. Results: The proposed MULTIPLEX-Lite method offered whole brain high resolution (<1mm3 voxel volume) MRA, PDW, T1W, aT1W, SWI, R2* maps and QSM in one 3-minute scan. Impact: The proposed MULTIPLEX-Lite method is among the most feasible and practical solutions for routine clinically friendly 3D high-resolution multi-parametric imaging practices.