Characterization of atlas based volumetric changes in unilateral 6-OHDA-induced Parkinson’s rat model
Motivation: Manual characterization of brain regions is studied without prior knowledge to identify changes in GM/WM volume in PD. Goal(s): Characterisation of GM and WM changes in 6-OHDA PD model as compared to sham controlApproach: Parcellated the rat brain into predefined regions using a rat atlas and performed the Wilcoxon rank signed rank test to identify significant changes in GM/WM volume. Results: Significant loss in GM volume of a few brain regions in PD and Sham observed in 3rd and 7th week. Increase in WM volume for 3rd week is observed. Impact: We identified GM loss and WM gain in a few brain regions without manual intervention which helps in understanding the structural changes in the whole brain in PD and Sham.
Authors
- Bharti Rana (ORCID: https://orcid.org/0000-0002-9985-1643)
- Suman Jain (ORCID: https://orcid.org/0000-0002-1428-605X)
- Sadhana Kumari (ORCID: https://orcid.org/0000-0003-0972-9634)
- Shefali Chaudhary (ORCID: https://orcid.org/0000-0003-4505-0506)
- S Senthil Kumaran (ORCID: https://orcid.org/0000-0002-4275-0139)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4118
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00