Cortical Microhemorrhage Presentation of Small Vessel Primary Angiitis of the Central Nervous System
Motivation: PACNS entails a biopsy for diagnosis, but only with an intermediate sensitivity. It is necessary to revisit PACNS with advanced imaging technique to provide a non-invasive diagnostic standard. Goal(s): We aim to find more pathological details with enough sensitivity and specificity to provide potential biomarkers for PACNS. Approach: 21 patients with small-vessel PACNS were included in this study. T1-MPRAGE, T2 T2*W, and SWI images were collected. Results: Our study highlighted the image features of patients with small-vessel PACNS with coral-like signs through 7T MRI. Due to the small patient cohort, no specific clinical differences between hemorrhagic and non-hemorrhagic patients were found. Impact: The signal characteristics of the coral-like sign represent cerebral cortical microhemorrhages with atrophy, which could be an important MRI pattern of small-vessel PACNS.
Authors
- Huabing Wang (ORCID: https://orcid.org/0000-0002-6848-2590)
- Lei Su (ORCID: https://orcid.org/0000-0002-5569-1991)
- Dehong Lu (ORCID: https://orcid.org/0000-0002-9473-9177)
- Xinghu Zhang (ORCID: https://orcid.org/0000-0002-5977-8648)
- Xiaoyu Shi (ORCID: https://orcid.org/0009-0009-4955-5836)
- Ying Fu (ORCID: https://orcid.org/0000-0002-3594-789X)
- Fu-Dong Shi
- Mengting Zhang
- De‐Cai Tian (ORCID: https://orcid.org/0000-0002-5153-2491)
- Yuan Li (ORCID: https://orcid.org/0000-0003-1803-6661)
- Zhe Zhang (ORCID: https://orcid.org/0000-0001-8220-8443)
- Jing Jing (ORCID: https://orcid.org/0000-0001-9822-5758)
- Chenyang Gao (ORCID: https://orcid.org/0000-0003-2390-0792)
- Ai Guo (ORCID: https://orcid.org/0000-0003-2658-0106)
- Gehong Dong
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1053
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00