Age dependency of abdominal fat depot volumes and proton density fat fractions in people with obesity
Motivation: As cardiometabolic risk in obesity is associated with specific body composition types, we aim at deciphering age-related body composition changes in people with obesity. Goal(s): To assess age-specific abdominal organ volume and proton density fat fraction (PDFF) in people with obesity and predict chronological age. Approach: An nnU-Net-based automatic pipeline was used to segment abdominal organs. Machine-learning-based methods were applied to predict chronological age based on the organs' volumes and PDFF in chemical-shift encoding-based MRI. Results: The best predictors for chronological age were increased visceral adipose tissue volume and elevated ectopic fat deposition in the paraspinal muscle, measured via proton density fat fraction. Impact: Age-specific differences in volumes and PDFF of abdominopelvic fat depots, and ectopic fat in liver and two muscles were found in people with obesity using automated segmentation on quantitative chemical-shift encoding-based MRI scans.
Authors
- Daniel Rueckert (ORCID: https://orcid.org/0000-0002-5683-5889)
- Dimitrios C. Karampinos (ORCID: https://orcid.org/0000-0003-4922-3662)
- Lisa Patzelt (ORCID: https://orcid.org/0000-0001-5594-4947)
- Jessie Han (ORCID: https://orcid.org/0000-0001-6008-4195)
- Meike Wiechert (ORCID: https://orcid.org/0000-0003-1972-6517)
- Arun Somasundaram (ORCID: https://orcid.org/0009-0007-2428-6858)
- Anna Reik (ORCID: https://orcid.org/0000-0002-1752-2994)
- Christina Holzapfel (ORCID: https://orcid.org/0000-0002-0155-9338)
- Johannes Raspe (ORCID: https://orcid.org/0009-0007-9628-1511)
- Mingming Wu (ORCID: https://orcid.org/0000-0002-8593-7091)
- Hans Hauner (ORCID: https://orcid.org/0000-0002-1682-5088)
- Daniela Junker (ORCID: https://orcid.org/0000-0002-7598-8485)
- Stella Naebauer
- Selina Rupp
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0836
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00