“Crafting” the olfactory atlas with brain regions and axonal bundles: application to COVID-19 subjects with anosmia
Motivation: Several pathologies, including COVID-19, affect the sense of smell, causing anosmia. Goal(s): The goal is to create an atlas that includes grey matter regions and white matter tracts involved in the olfactory circuit. Approach: Grey matter regions involved in the olfactory circuit were selected and an atlas of tracts connecting pairs of regions was extracted using tractography. The atlas was used on subjects with anosmia caused by COVID-19 to investigate changes in grey matter density (voxel-based analysis) and quantitative microstructural maps (mean diffusivity and fractional anisotropy). Results: Structural alterations were found in subjects with anosmia, mainly in the cerebellum. Impact: The created olfactory circuit atlas, which includes grey matter regions and axonal bundles, can be crucial for studying pathologies involving alterations in the olfactory circuit. The atlas was useful to detect structural alterations in subjects with anosmia caused by COVID-19.
Authors
- Janine Makaronidis (ORCID: https://orcid.org/0000-0003-1045-2871)
- Fulvia Palesi (ORCID: https://orcid.org/0000-0001-5027-8770)
- Elena Grosso
- Claudia A. M. Gandini Wheeler‐Kingshott (ORCID: https://orcid.org/0000-0002-4832-1300)
- Francesco Grussu (ORCID: https://orcid.org/0000-0002-0945-3909)
- Marios Yiannakas (ORCID: https://orcid.org/0000-0003-4986-446X)
- Marta Gaviraghi (ORCID: https://orcid.org/0000-0001-7427-845X)
- Ferrán Prados (ORCID: https://orcid.org/0000-0002-7872-0142)
- Egidio D’Angelo (ORCID: https://orcid.org/0000-0002-6007-7187)
- Baris Kanber (ORCID: https://orcid.org/0000-0003-2443-8800)
- Rebecca S. Samson (ORCID: https://orcid.org/0000-0002-0197-702X)
- Marco Battiston (ORCID: https://orcid.org/0000-0003-2231-2251)
- Anita Monteverdi (ORCID: https://orcid.org/0000-0003-0071-9325)
- Eleonora Lupi
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3020
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00