Deciphering the Mediator Role of White Matter Function in Age-Related Cognitive Decline
Motivation: Unraveling how age-related changes in brain structure and function affect cognitive functions. Goal(s): To determine the mediation role of white matter functional metrics in cognitive decline with aging. Approach: Employing fMRI, graph theory, and mediation analysis to assess how the effect of changes in WM BOLD activity with age influence or reflect cognitive performance. Results: Identified significant white-matter mediators linking age to cognitive performance. Impact: Contributes a fresh perspective to our understanding of the functional architecture of the aging brain.
Authors
- John C. Gore (ORCID: https://orcid.org/0000-0002-9480-0900)
- Yurui Gao (ORCID: https://orcid.org/0000-0002-4339-5351)
- Adam W. Anderson (ORCID: https://orcid.org/0000-0002-3788-6138)
- Muwei Li (ORCID: https://orcid.org/0000-0003-3596-9287)
- Kurt G. Schilling (ORCID: https://orcid.org/0000-0003-3686-7645)
- Soyoung Choi (ORCID: https://orcid.org/0000-0001-7165-4691)
- Bennett A. Landman (ORCID: https://orcid.org/0000-0001-5733-2127)
- Zhaohua Ding (ORCID: https://orcid.org/0000-0002-1805-2955)
- Zhongliang Zu (ORCID: https://orcid.org/0000-0001-7361-7480)
- Lyuan Xu (ORCID: https://orcid.org/0000-0002-9791-0806)
- Fei Gao (ORCID: https://orcid.org/0000-0002-4343-0276)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3877
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00