Feasibility of 3D APT and NOE mapping using extrapolated semi-solid magnetization transfer reference fitting in brain tumors

Motivation: Currently, APT and NOE imaging with extrapolated semi-solid magnetization transfer reference (EMR) fitting has been performed with single-slice acquisition. Goal(s): To demonstrate the feasibility of 3D APT and NOE imaging with EMR fitting using the 3D CEST sequence with CS-SENSE in patients with brain tumors. Approach: 3D CEST imaging with CS-SENSE was adjusted to clinical scan. EMR fitting was performed on the 3D data. Results: 3D APT and NOE mapping was feasible in all patients with brain tumors by using the 3D CEST imaging with CS-SENSE within a clinically acceptable acquisition time. Impact: The feasibility of 3D APT and NOE mapping using 3D CEST imaging with CS-SENSE was demonstrated. Quantitative evaluation of APT and NOE on multiple slices allows for the quantitative assessment for the entire tumor area.