MRS Investigations of the Metabolomic Pathophysiology of Acute Respiratory Distress Syndrome (ARDS)

Motivation: ARDS currently has unacceptable high mortality and long-term complications, which underscores the urgency of improving our understanding and management of ARDS. Goal(s): To establish pathology-guided serum metabolomic profiles for ARDS patients by comparing them with profiles from patients without ARDS. Approach: We measured ARDS serum using high-resolution magic angle spinning (HRMAS) magnetic resonance spectroscopy (MRS) to establish serum metabolomic profiles for ICU-patients with and without ARDS following various clinical outcomes. Results: Serum specimens measured by HRMAS MRS enables the predictions of ARDS patient outcome in ICU. Impact: Our initial results highlight the feasibility of HRMAS MRS in investigating ARDS metabolomic mechanisms, which may lay the basis for future diagnostic and therapeutic research, offering promising prospects for innovation in ARDS management.