Repeatability of Cardiopulmonary Oscillations Imaged with 129Xe MRI

Motivation: Keyhole-based 129Xe MR imaging of cardiopulmonary oscillations is a promising technique, but repeatability has not been studied. Goal(s): To evaluate the repeatability of RBC oscillation amplitude metrics derived from 129Xe MRI across multiple time points and correlate these with dynamic spectroscopy measurements. Approach: A cohort of 21 participants underwent 129Xe gas exchange MRI and MRS scans using consortium protocols. Repeatability was assessed using Bland-Altman analysis, with Spearman correlation for cross-modality comparisonResults: The study found repeatability to be high for mean oscillation amplitude but moderate for the binning-derived metrics. Image-derived mean oscillation amplitude correlated strongly to that derived from MRS. Impact: Analysis of 129Xe MRI cardiopulmonary oscillation metrics show moderate repeatability across same-session scans.