Macromolecule Exchange and Non-Exchange Protons Multiparametric Imaging of Knee: using ZAP/CEST and T2* Mapping with δTE Ultra-Short TE.

Motivation: The study addresses the need for knee injury diagnosis by advancing MRI techniques to capture both structural and biochemical tissue characteristics. Goal(s): The goal is to develop advanced MRI biomarkers by integrating Z-spectrum/CEST with UTE techniques, improving visualization of knee structures for detection of injuries and pathologiesApproach: We used novel Z-spectrum/CEST and UTE sequences to characterize proton exchange and obtain detailed T2* mapping, aiming to reveal precise biochemical and ultrastructural knee tissue details. Results: Findings demonstrate improved T2* mapping and proton characterization in knee tissues, suggesting potential biomarkers for early pathology identification, although further validation is necessary for clinical application. Impact: Multiparametric imaging of macromolecular exchange and non-exchange protons using ZAP/CEST MRI and UTE imaging with tight intervals δTE offers detailed knee tissue visualization, with potential for developing precise diagnostic biomarkers.