Towards cardiac DMI at clinical field strengths
Motivation: Deuterium metabolic imaging (DMI) might permit mapping of cardiac metabolism by MRI. Goal(s): To port DMI tools developed at 11.7T for mice to 3T, and develop methods for cardiac DMI. Approach: Simulations, phantoms, and in vivo studies were conducted to measure SNR at 3T, develop an optimized protocol, and account for B0 inhomogeneity. Results: At 11.7T, cardiac DMI was tested in a control mouse. At 3T, phantom studies showed that multi-echo bSSFP methods yield increased SNR vs. GRE. B0-mapping helps in isolating the metabolites in phantoms. Impact: Development of DMI tools for use in cardiac DMI at clinical field strengths.
Authors
- Lauren A. Baldassarre (ORCID: https://orcid.org/0000-0003-4173-3449)
- Dana C. Peters (ORCID: https://orcid.org/0000-0001-7556-4642)
- Jennifer M. Kwan (ORCID: https://orcid.org/0000-0002-4715-1848)
- Monique Thomas
- Henk De Feyter
- Daniel Coman (ORCID: https://orcid.org/0000-0002-6289-0817)
- Robin de Graaf (ORCID: https://orcid.org/0000-0002-0303-4615)
- Jie Xiang (ORCID: https://orcid.org/0000-0002-6637-5097)
- Peter Herman
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3052
- Primary Topic
- Cardiac pacing and defibrillation studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00