Assessment of Renal Water Exchange by T2 Selective Labeling

Motivation: Alterations of renal water transport and exchange may reflect kidney function and disease. Goal(s): To develop and test a novel sequence for quantitative assessment of intrarenal fluid exchange. Approach: We developed a T2 selective labeling sequence for water exchange quantification and tested it on healthy subjects. Results: Images showed a characteristic spatial distribution of signal with increased signal in the renal medulla, in support of its detection and assessment of fluid exchange. Impact: Exchange imaging by T2 selective saturation may open new possibilities for the study of water transport and exchange and the diagnosis of renal disorders.