Altered dynamics of global cortical depth connectivity in depression
Motivation: A previous own study in healthy volunteers indicated that global laminar connectivity is highly dynamic, suggesting that it could be sensitive to altered brain conditions. Goal(s): Does global laminar connectivity change in depression? Approach: We acquired high-resolution fMRI data from patients before and after treatment and conducted a dynamic connectivity analysis focused on cortical depth. Results: The prevalence of the depth-connectivity states co-evolved with the psychometric scores of patients. Impact: The presented results may motivate other researchers working on laminar fMRI to average across ROIs and evaluate the effect of diverse brain conditions on the global component of depth-dependent connectivity, whose potential relevance is suggested by our preliminary studies.
Authors
- Seong Dae Yun (ORCID: https://orcid.org/0000-0001-7398-1899)
- Ravichandran Rajkumar (ORCID: https://orcid.org/0000-0001-5875-5316)
- Shukti Ramkiran (ORCID: https://orcid.org/0000-0001-8253-1873)
- Jana Hagen (ORCID: https://orcid.org/0009-0008-2861-6719)
- Tanja Veselinović (ORCID: https://orcid.org/0000-0001-7906-6966)
- Irene Neuner (ORCID: https://orcid.org/0000-0002-5164-8873)
- Patricia Pais‐Roldán (ORCID: https://orcid.org/0000-0002-9381-3048)
- N. Jon Shah (ORCID: https://orcid.org/0000-0002-8151-6169)
- Gereon Johannes Schnellbächer
- Areej Al Okla
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1113
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00