Tracking Age-Related Changes using NOEMTR in Brain Subregions at 3T
Motivation: Demyelination and lipid degeneration occurs as the human brain ages. Our motivation was to investigate the age-dependent variations of these lipids changes in subcortical gray matter regions using NOEMTR in the brains of 15 subjects. Goal(s): To determine the correlation of the human brain NOEMTR metric with age. Approach: We performed NOE MRI experiments on multiple subjects from ages (24Y-76Y) using NOEMTR at 3T. Results: The Spearman’s correlation coefficient indicates that NOEMTR declines in several brain subregions with aging. Impact: NOEMTR can be used to track lipid changes in white and gray matter subregions of the aging brain.
Authors
- Ravi Prakash Reddy Nanga (ORCID: https://orcid.org/0000-0002-3644-5656)
- Ravinder Reddy (ORCID: https://orcid.org/0000-0003-4580-2392)
- Ryan Armbruster (ORCID: https://orcid.org/0000-0003-0469-8816)
- Blake Benyard (ORCID: https://orcid.org/0000-0002-2480-4164)
- Mark A. Elliott (ORCID: https://orcid.org/0000-0003-2560-8760)
- Neil Wilson (ORCID: https://orcid.org/0009-0002-7766-2929)
- Dushyant Kumar
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3865
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00