Alterations in superficial white matter tracts are associated with pathological deposition in early-stage Alzheimer’s disease
Motivation: Between-cortical connections largely depend on the superficial white matter (SWM) fibers, which are less studied in the AD continuum. Goal(s): To determine the relationship between superficial white matter (SWM) fiber microstructure and local pathology, and the SWM's impact on cognition. Approach: We defined cohort groups in the early AD continuum. We quantified the microstructure of SWM fiber tracts (diffusion MRI) and the regional pathological deposition (PET). We analyzed associations between SWM fiber microstructure and regional pathologies in cortical areas connected by the tract. Results: SWM tract microstructure is affected by pathology in the cortical regions connected by the tract, and this affects memory. Impact: We localize pathology-affected SWM connections, assess their roles in cognition, and provide new insights into white matter abnormalities in the AD continuum.
Authors
- Kaicheng Li (ORCID: https://orcid.org/0000-0001-5500-7523)
- Peiyu Huang (ORCID: https://orcid.org/0000-0003-4226-9369)
- Xiao Luo (ORCID: https://orcid.org/0000-0003-1743-7842)
- Fan Zhang (ORCID: https://orcid.org/0000-0002-5520-3628)
- Xinfeng Yu
- Minming Zhang (ORCID: https://orcid.org/0000-0003-0145-7558)
- Xiaopei Xu (ORCID: https://orcid.org/0000-0002-0342-383X)
- Lauren J. O’Donnell (ORCID: https://orcid.org/0000-0003-0197-7801)
- Shuyue Wang (ORCID: https://orcid.org/0000-0002-6099-4452)
- Jianzhong Sun (ORCID: https://orcid.org/0000-0002-7700-5198)
- Hui Hong (ORCID: https://orcid.org/0000-0003-2084-203X)
- Qingze Zeng (ORCID: https://orcid.org/0009-0001-5894-4405)
- Yeerfan Jiaken
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0759
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00