Gray-White Matter Boundary Z-Score and Its Volume as Imaging Biomarkers of Alzheimer’s Disease
Motivation: Alzheimer's disease (AD) presents typically gray matter atrophy and white matter abnormalities in neuroimaging. Goal(s): Exploring gray-white matter boundary Z-score (gwBZ) and its tissue volume (gwBTV) between patients with Alzheimer’s disease (AD), amnestic mild cognitive impairment (MCI), and cognitively normal (CN) elderly participants. Approach: Three-dimensional T1-weight images of a total of 227 participants were acquired to calculate gwBZ and gwBTV, prospectively. Results: Both gwBZ and gwBTV were reduced in AD, were positively correlated with cognitive function, and could accurately discriminate AD from CN . Impact: gwBZ and gwBTV could be a useful tool for monitoring AD progression and diagnosis.
Authors
- Hak Young Rhee (ORCID: https://orcid.org/0000-0002-3016-2591)
- Soonchan Park (ORCID: https://orcid.org/0000-0001-6057-7117)
- Geon‐Ho Jahng (ORCID: https://orcid.org/0000-0001-8881-1884)
- Yunan Tian (ORCID: https://orcid.org/0000-0002-7069-2757)
- Chang‐Woo Ryu
- Wook Jin (ORCID: https://orcid.org/0000-0002-1616-5091)
- Jang-Hoon Oh (ORCID: https://orcid.org/0000-0002-4251-5470)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4055
- Primary Topic
- Brain Tumor Detection and Classification
- Type
- article
- Field-Weighted Citation Impact
- 0.00