The importance of dynamic contrast-enhanced MRI in preoperative prediction of glioma genotype and prognosis

Motivation: Accurate preoperative noninvasive diagnosis and classification of diffuse gliomas have a significant impact on clinical management and are of significant prognostic importance. Goal(s): To investigate the diagnostic efficacy and clinical value of preoperative DCE-MRI in predicting genotype and prognosis of glioma. Approach: Adult diffuse gliomas were enrolled. Univariate and multivariate logistic or cox regression analysis are performed for diagnosing glioma gene and prognosis. Results: Preoperative DCE-MRI exhibits favorable diagnostic capabilities in identification of IDH mutation status with AUC value of 0.77, 1p19q codeletion with AUC value of 0.71, and CDKN2A/B homozygous deletion with AUC value of 0.93, and assessment of glioma prognosis. Impact: This study highlighted potential clinical application of DCE-MRI by demonstrating the robust diagnostic performance of DCE-derived parameters. These parameters exhibited not only excellent diagnostic accuracy in identifying functional biomarkers such as IDH, 1p19q and CDKN2A/B, but also in predicting prognosis.