Using Virtual Magnetic Resonance Elastography and IVIM to Evaluate Placental Microstructure and Microcirculation in Gestational Hypertension

Motivation: Detecting placental dysfunction using MRI before placental macrovascular lesions by ultrasound may help the early identification of placental pathologic changes in gestational hypertension (GH). Goal(s): To explore changes in placental elasticity and perfusion in GH and control groups using MRI. Approach: Placental elasticity and perfusion were assessed using virtual magnetic resonance elastography (vMRE) and intravoxel incoherent motion (IVIM). The vMRE and IVIM parameters, MR morphologic parameters, and ultrasound and lab test results were compared between the two groups. Results: Placental stiffness and perfusion fraction helped distinguish between the two groups, with no substantial differences in the other parameters. Impact: Virtual magnetic resonance elastography and intravoxel incoherent motion can quantify placental elasticity and circulation at the microscopic level, and are superior to the ultrasound parameters, in gestational hypertension. They may serve as a vital noninvasive supplement to assess placental dysfunction.