Integration of myelin-sensitive biophysical features in virtual brain models: towards healthy and pathological Brain Digital Twins
Motivation: The Virtual Brain (TVB) is a neuroinformatic platform used to perform brain dynamic simulations integrating subject-specific imaging data. In standard TVB the input conduction velocity is fixed, making it insensitive to local effective measures of myelin content. Goal(s): Here we parameterized signal conduction velocity for TVB simulations. Approach: Considering myelin role in efficient neural conduction, myelin measures were integrated into TVB. Results: Making TVB sensitive to myelin content highlights variations in simulation outcomes with potential improvements in capturing spatiotemporal dynamics of brain activity. This advancement opens perspectives for realizing more accurate subject-specific simulations, representing a new step towards brain digital twinning. Impact: Brain Digital Twin technologies will transform personalized medicine, providing a better understanding of pathophysiological underpinnings of diseases. Our study demonstrates how simulating brain activity with The Virtual Brain model improves when integrating subject-specific neural conduction values, calculated from myelin measures.
Authors
- Nicolò Rolandi (ORCID: https://orcid.org/0000-0002-6801-9440)
- Fulvia Palesi (ORCID: https://orcid.org/0000-0001-5027-8770)
- Alessandra Marinelli (ORCID: https://orcid.org/0000-0002-6501-5364)
- Elena Grosso
- Jed Wingrove (ORCID: https://orcid.org/0000-0002-0454-1299)
- Claudia A. M. Gandini Wheeler‐Kingshott (ORCID: https://orcid.org/0000-0002-4832-1300)
- Francesco Grussu (ORCID: https://orcid.org/0000-0002-0945-3909)
- Marios Yiannakas (ORCID: https://orcid.org/0000-0003-4986-446X)
- Marta Gaviraghi (ORCID: https://orcid.org/0000-0001-7427-845X)
- Ferrán Prados (ORCID: https://orcid.org/0000-0002-7872-0142)
- Madiha Shatila
- Egidio D’Angelo (ORCID: https://orcid.org/0000-0002-6007-7187)
- Baris Kanber (ORCID: https://orcid.org/0000-0003-2443-8800)
- Rebecca S. Samson (ORCID: https://orcid.org/0000-0002-0197-702X)
- Marco Battiston (ORCID: https://orcid.org/0000-0003-2231-2251)
- Anita Monteverdi (ORCID: https://orcid.org/0000-0003-0071-9325)
- Antonio Ricciardi (ORCID: https://orcid.org/0009-0001-7461-051X)
- Eleonora Lupi
- Claudia Casellato
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1111
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00