Ventilation and Gas Exchange Delay maps in Pre-clinical Thoracic Insufficiency Syndrome Models using Dynamic Hyperpolarized-Xenon MRI
Motivation: The pressing need to develop and evaluate novel treatments of thoracic insufficiency syndrome (TIS), a condition with significant implications for compromised pulmonary growth and function. Goal(s): To gain deeper insights into the altered lung function associated with TIS, ultimately improving patient care and outcomes. Approach: Dynamic hyperpolarized-xenon-129 MRI was used to assess ventilation and gas exchange dynamics in pre-clinical models of TIS. Results: Significant ventilation and gas exchange delays were found in the TIS animals compared to the healthy ones. Impact: Our findings hold the promise to improve TIS assessment and treatment monitoring by providing crucial insights into altered lung function. This study offers a valuable tool for clinicians/researchers, fostering improved patient care and stimulating further TIS management and intervention research.
Authors
- L. Loza (ORCID: https://orcid.org/0000-0001-8812-7118)
- Hooman Hamedani (ORCID: https://orcid.org/0000-0002-9385-3082)
- Thomas P. Schaer (ORCID: https://orcid.org/0000-0002-4340-8212)
- Stephen Kadlecek (ORCID: https://orcid.org/0000-0002-5131-7994)
- Patrick J. Cahill (ORCID: https://orcid.org/0000-0002-7129-1007)
- Klaus Hopster (ORCID: https://orcid.org/0000-0003-0329-3083)
- Benjamin P. Sinder
- Kai Ruppert (ORCID: https://orcid.org/0000-0002-7292-6019)
- Mostafa A. Ismail (ORCID: https://orcid.org/0000-0001-7530-9764)
- F. Amzajerdian (ORCID: https://orcid.org/0000-0002-1326-9581)
- Madeline Boyes (ORCID: https://orcid.org/0009-0003-0386-9123)
- Rahim R. Rizi
- Brian Snyder
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0295
- Primary Topic
- Atomic and Subatomic Physics Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00