Development of a Whole Abdominopelvic Variable Resolution Hyperpolarized 13C MRI Approach for Advanced Prostate Cancer Clinical Research
Motivation: Monitoring the progression or response of advanced prostate metastases is a current clinical unmet need that is not reliably delineated with current CT and PET. Goal(s): Here, we developed a high-resolution whole abdominopelvic [1-13C]pyruvate HP MRI approach for the metabolic biomarker characterization of metastases in prostate cancer patients. Approach: A variable-resolution imaging approach was used to provide high-resolution [1-13C]pyruvate, robust spatiotemporal denoising and B1+ variation correction methods were used to quantify the rate-constant for the conversion of [1-13C]pyruvate to lactate, kPL. Results: Improved conspicuity of [1-13C]pyruvate distribution and kPL conversion maps of metastatic lesions were achieved with the new approach. Impact: The improvement in [1-13C]pyruvate resolution and clear delineation of highly metabolically active metastatic lesions in kPL maps demonstrated the potential of [1-13C]pyruvate HP MRI in advanced prostate cancer.
Authors
- Philip Lee (ORCID: https://orcid.org/0000-0002-5783-1599)
- Ivan de Kouchkovsky (ORCID: https://orcid.org/0000-0002-3092-3565)
- John V. Kurhanewicz (ORCID: https://orcid.org/0000-0002-3544-5339)
- Daniel B. Vigneron (ORCID: https://orcid.org/0000-0001-5795-8699)
- Tanner Nickles (ORCID: https://orcid.org/0000-0003-4322-2431)
- Peder E. Z. Larson (ORCID: https://orcid.org/0000-0003-4183-3634)
- Yaewon Kim (ORCID: https://orcid.org/0000-0003-1016-1572)
- Robert Bok (ORCID: https://orcid.org/0000-0003-1737-9056)
- Jeremy W. Gordon (ORCID: https://orcid.org/0000-0003-2760-4886)
- Michael A. Ohliger (ORCID: https://orcid.org/0000-0001-6878-8189)
- Daniel Gebrezgiabhier (ORCID: https://orcid.org/0000-0002-8118-3931)
- Rahul Aggarwal (ORCID: https://orcid.org/0000-0001-7003-7982)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-3640-8951)
- Hsin-Yu Chen (ORCID: https://orcid.org/0009-0007-9310-4122)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3515
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00