Obtaining exchange rate maps using Multitasking SS-CEST

Motivation: To make qCEST clinically feasible by reducing the imaging timeGoal(s): Multitasking steady-state (SS) approach was used to get 3D volume acquisition that reduced the imaging time per slice by a factor of 22 as compared to conventional qCEST. Approach: 6 Yucatan minipigs were scanned at four time points post interverbal disk injury. The injury was done at the lower three lumbar discs. Conventional 2D qCEST and 3D Multitasking steady state CEST were performed. Results: Scan time for conventional qCEST is 24 minutes/slice while the imaging time for Multitasking SS qCEST is 36 minutes for 32 slices, representing a factor of 22 improvement. Impact: This study represents the initial step in validating an accelerated qCEST using Multitasking. The development of MRI-based pain assessment biomarkers in this model is crucial for advancing our understanding and treatment of lower back pain.