Quantification of BBB Permeability in glioma using ASL with tissue specific T2 values
Motivation: Blood brain barrier arterial spin labeling (BBB-ASL) could assess BBB integrity. However, the assumption of homogeneous T2 in data fitting might be broken in gliomas. Goal(s): To evaluate the BBB integrity in gliomas with regional tissue-specific T2. Approach: A mono-exponential T2 fitting was used to obtain tissue-specific T2 values to estimate time of water exchange (Tex) and perfusion (CBF) in the tumor, normal-appearing white (NAWM), and gray matter (NAGM) using ExploreASL. Results: Higher Tex in NAWM, and lower Tex in the tumor and NAGM were observed and the tumor heterogeneity was better depicted when tissue-specific T2 values were used. Impact: Water exchange and perfusion maps are highly affected by the tissue T2 value used in BBB-ASL data processing. Applying tissue-specific T2 correction has resulted in a more reliable evaluation of BBB integrity in gliomas.
Authors
- Alp Di̇nçer (ORCID: https://orcid.org/0000-0001-9158-8353)
- Klaus Eickel (ORCID: https://orcid.org/0000-0002-5700-2029)
- Simon Konstandin (ORCID: https://orcid.org/0000-0002-8143-2221)
- Vera C. Keil (ORCID: https://orcid.org/0000-0001-8699-3506)
- Nora-Josefin Breutigam (ORCID: https://orcid.org/0000-0002-8528-9792)
- Daniel Hoinkiss (ORCID: https://orcid.org/0000-0002-3358-7296)
- Henk J. M. M. Mutsaerts (ORCID: https://orcid.org/0000-0003-0894-0307)
- Amnah Mahroo (ORCID: https://orcid.org/0009-0005-8480-0965)
- Esin Öztürk-Işık (ORCID: https://orcid.org/0000-0002-8997-878X)
- Koray Özduman (ORCID: https://orcid.org/0000-0002-3543-0401)
- Jan Petr (ORCID: https://orcid.org/0000-0002-3201-6002)
- Beatriz Padrela (ORCID: https://orcid.org/0000-0001-6836-9443)
- Ayşe İrem Çetin (ORCID: https://orcid.org/0000-0002-9298-0565)
- Gülce Turhan (ORCID: https://orcid.org/0000-0003-2645-8442)
- Matthias Günther (ORCID: https://orcid.org/0000-0002-2650-7956)
- Ayca Ersan-Danyeli
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3862
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00