White-matter functional networks changes in PD patients with L-dopa induced dyskinesia

Motivation: Functional connectivity between white-matter networks maybe a neuroimaging biomarker of PD with L-dopa induced dyskinesia (LID). Goal(s): The aim of this research is to investigate changes of the white-matter functional networks in PD with LID. Approach: The construction of white-matter network was achieved by using K-means clustering while FC was also calculated. Results: A decreasing trend (not significant) was also found between LID and noLID group. FC between WM2 and WM11 in LID group showed a significantly positive correlation with MMSE, while a negative relation between FC and MMSE was found in noLID group. Impact: The study showed that decreased FC between white-matter networks and their influence on clinical performance may indicated the appearance of PD and symptom of LID.