Identification of glioma IDH genotypes using time-dependent diffusion magnetic resonance imaging-based microstructural mapping

Motivation: Time-diffusion-dependent diffusion MRI (t-dMRI)provides quantitative imaging of cellular microstructure; however, its value in diagnosing molecular subtypes of IDH in gliomas remains unknown.<stork-writing-assistant></stork-writing-assistant><stork-writing-assistant></stork-writing-assistant>Goal(s): Molecular subtypes of IDH were diagnosed using quantitative time-dependent diffusion imaging parameters.<stork-writing-assistant></stork-writing-assistant><stork-writing-assistant></stork-writing-assistant>Approach: t-dMRI was acquired using OGSE and PGSE sequences, and quantitative parameters were then fitted using the Imaging Microstructural Parameters Using Limited spectrally edited diffusion(IMPULSED) method and evaluated for diagnostic potency for molecular subtypes of IDH in gliomas. <stork-writing-assistant></stork-writing-assistant><stork-writing-assistant></stork-writing-assistant>Results: t-dMRI can identify IDH genotypes, and intracellular fraction (fin) reflects the actual state of tumor cells.<stork-writing-assistant></stork-writing-assistant><stork-writing-assistant></stork-writing-assistant>Impact: t-dMRI can non-invasively identify IDH genotype.<stork-writing-assistant></stork-writing-assistant><stork-writing-assistant></stork-writing-assistant>