A Comparative Study of DTI and SANDI for Discriminating Alzheimer's Pathology in a 5xFAD Mouse Model

Motivation: This study aims to assess DTI and SANDI's ability to detect Alzheimer's disease (AD) in a 5xFAD mouse model. Goal(s): Employ logistic regression and ROC curve analysis on data from 166 brain regions to compare the performance of DTI and SANDI. Approach: Data collection from 5xFAD mice, brain region segmentation, logistic regression modeling, and ROC curve generation. Results: SANDI exhibits superior AD detection capabilities compared to DTI, as evidenced by a higher AUC value, indicating enhanced sensitivity and specificity. These findings highlight SANDI's potential for nuanced preclinical AD biomarkers. Impact: Implementing SANDI over DTI may improve early detection of Alzheimer's, potentially leading to better patient outcomes through earlier intervention and more targeted therapeutic strategies in preclinical settings.