Towards Reproducible Intravoxel Incoherent Motion (IVIM) Analysis: The ISMRM Open Science Initiative for Perfusion Imaging

Motivation: Lack of validated and open-source intravoxel incoherent motion (IVIM) post-processing and fitting code is hindering reproducible research, limiting the validation and large-scale roll-out of IVIM imaging. Goal(s): To create an open-source code repository for IVIM-related code. Approach: Scientists interested in IVIM are encouraged to upload their code to our open-source code repository built by the ISMRM OSIPI task force 2.4, where automated testing and evaluation based on reference data are used to enable quality control of the code. Results: As of November 2023, 19 code contributions have been submitted by 6 different institutes, all passing automated testing. Impact: The work of ISMRM OSIPI task force 2.4 enables an open-source platform for validated code relevant to intravoxel incoherent motion (IVIM) imaging, thus reducing duplicate development, improving reproducibility, and serving as a benchmark for future methods.