Hippocampal amide proton transfer value is associated with the imaging marker and total burden of cerebral small vessel disease

Motivation: Exploring the CSVD imaging markers can provide insights into the pathophysiology of CSVD, which is crucial for understanding its etiology, development, and clinical interventions. Goal(s): To investigate potential variations in hippocampal APT values among individuals with CSVD imaging markers and varying degrees of CSVD total burden. Approach: All the participants conducted the cognitive assessment and the MRI scans. And statistical analysis was used for evaluation. Results: The hippocampal APT values among different CSVD total load groups were significantly different (p<0.001). The mediation models demonstrated that the APT values of the hippocampus partially mediated the association between CSVD total load and MoCA score. Impact: Hippocampal APT values may serve as a biomarker for the early detection of neurodegeneration in CSVD patients.