Comparative analysis of brain network connectivity changes in Alzheimer's and Parkinson's disease with mild cognitive impairment: an ICA study

Motivation: The pathogenesis of cognitive dysfunction may be different, particularly in terms of macroscopic manifestations within neural transmission pathways, which still require further exploration. Goal(s): The aim of this study was to quantify changes in fMRI intra and inter-network connectivity in AD-MCI and PD-MCI using independent component analysis (ICA). Approach: Nine RSNs were identified in 33 AD-MCI, 55 PD-MCI and 34 HCs using ICA method, and further their intra-and inter-network FC were compared in three groups. Results: The results showed that the brain network changes in AD-MCI patients and PD-MCI patients were mainly concentrated in different brain network. Impact: By investigating the pathways and compensatory mechanisms underlying cognitive dysfunction arising from different etiologies, we aim to explore potential imaging-based diagnostic approaches and therapeutic strategies for clinical treatment strategy, which is enhancing the prognosis and quality of life for patients.