Serum metabolic profiling of human valve diseases based on proton NMR spectroscopy

Motivation: Heart valve disease (HVD) is a complex condition with a poorly known pathogenesis. Goal(s): NMR-based serum metabolomics of HVD patients (aortic, mitral valve, and double valve replacement) and healthy controls to identify potential biomarkers for HVD. Approach: Proton NMR spectroscopy Results: The results obtained from PLS-DA and VIP score plots of metabolites in serum showed a separation between patients with HVD and HC. Impact: To understanding the potential metabolic alteration such as BCAA, and fatty acids, amino acids, and carbohydrate metabolism associated with inflammation, oxidative stress, and tissue degradation of HVD.