Altered static and dynamic functional network connectivity in individuals with subthreshold depression: a resting-state fMRI study

Motivation: identifying the neural pathology mechanisms has the potential value to elucidate risk factors and prognostic markers for subthreshold depression(StD)Goal(s): FNC is a useful imaging tool in detecting the neuro-mechanism of the brain Approach: This study involved in the static functional network connectivity (sFNC) and dynamic functional network connectivity (dFNC) to investigate the FNCdifferences between the StD and HCs groupsResults: StD demonstrated altered FNC in executive control network (ECN), default mode network (DMN), sensorimotor network (SMN) and dorsal attentional network (DAN), in addition, Std had increased mean dwell time and fraction time in a weak connected state concerning the dFNC analysis. Impact: The sFNC and dFNC findings could enrich our understanding of the large-scale resting-state FNC abnormalities in StD individuals, which could provide insights for a better understanding of the behind neural mechanisms