Mammalian Species: Development of Basic Tools for Standardized Brain Image Analysis

Motivation: Establishing standard brain images for various mammalian species may be useful in brain imaging analysis. Goal(s): The current research aimed to establish a foundation for brain image analysis tools in a variety of mammalian species, including cats and marmosets, for which standard brain data are scarce. Approach: For each species, we attempted to create an image of average brain using a nonrigid transformation algorithm. We also evaluated the quality of the average brain images by changing the number of subjects. Results: We were able to create an image the average human, cat, marmoset, and mouse brain based on T1- and T2-weighted images. Impact: This study provides an important foundation for the creation of standard brain images of various animal species and for the evaluation of individual differences.