Assessment of Glymphatic Function in Acute High Altitude Reaction: by diffusion tensor image analysis along the perivascular space (DTI-ALPS)

Motivation: Diffusion tensor image analysis along the perivascular space(DTI-ALPS) is a novel non-invasive assessment of the activity of the human brain's lymphoid system, which is currently being used to assess the function of the lymphoid system in patients with acute high altitude reaction(AHAR). Goal(s): To evaluate the activity of the glymphatic system in patients with AHAR using DTI-ALPS, and explore the relationship between lymphoid function and disease severity. Approach: Recruited 5 patients with AHAR and calculated ALPS index, Pearson correlation analysis were used for evaluating relationship between ALPS index and diagnostic scoring. Results: There was a significant correlation between DTI-ALPS and disease scores(r=-0.964 P=0.005). Impact: DTI-ALPS is a novel non-invasive assessment of the activity of the human brain's lymphoid system, which is currently being used to assess the function of the lymphoid system in patients with AHAR.