Graph theory-based analysis reveals neural anatomical network alterations in chronic PTSD in World Trade Center responders

Motivation: To uncover the neuropathological changes that influence the persistence and progression of symptoms in individuals with chronic Post-Traumatic Stress Disorder (PTSD), particularly among World Trade Center (WTC) responders. Goal(s): The goal is to identify and characterize the neuroanatomical differences associated with chronic PTSD in World Trade Center responders using diffusion tensor neuroimaging and graph theory techniques. Approach: employing graph theory to examine network alterations using brain diffusion images. Results: The results of the study indicated significant differences in the neuroanatomical distances between white matter nodes—measured by weighted characteristic path lengths (CPL)—in World Trade Center responders with chronic PTSD compared to those without PTSD. Impact: The impact of this study lies in advancing the understanding of PTSD as a disorder with anatomical basis. The association of increased characteristic path lengths with PTSD suggests that the disorder might involve diminished efficiency in the brain's communication networks.