Diagnostic value of GRASP in the differentiation of breast malignancy

Motivation: Breast MRI plays a vital role in early breast cancer screening, staging, and surgical guidance. The core technology used in breast MRI is DCE-MRI. Goal(s): This study aims to assess the effectiveness of using the GRASP sequence in distinguishing highly malignant breast lesions. Approach: We utilized the GRASP sequence, which offers high temporal resolution, to compare and analyze the microvascular characteristics of benign and malignant breast lesions. Results: We found that Kep was significantly higher in malignant lesions compared to benign lesions, suggesting a potential relationship between the abundant blood supply and high wall permeability observed in malignancies. Impact: The GRASP dynamic enhancement technique provides both morphological and hemodynamic characteristics of breast lesions, aiding in the differentiation of high-grade malignancies.