Location matters: Altered interhemispheric homotopic connectivity in post-stroke dyskinesia

Motivation: How stroke at different locations affects homotopic connectivity remains incompletely understood. Goal(s): This study aimed to examine how motor deficits resulting from acute stroke in different brain regions impact homotopic connectivity. Approach: Patients with dyskinesia were included and divided into 4 demographically matched subgroups by stroke location: frontoparietal, radiation coronal, basal ganglia, and brain stem. Additional 37 matched healthy controls were also recruited. Interhemispheric homotopic functional and structural connectivity was obtained by resting-state functional MRI and diffusion tensor imaging. Results: Our results suggest that post-stroke motor deficits in different regions implicate different links from cortical to subcortical areas. Impact: Alterations in lesion topography and regional functional homotopy provide new insights into the understanding of neural basis of motor disorders and also inform potential individualized precisive targets.