Cardiovascular assessment of diastolic dysfunction in people living with the HIV: correlation with markers of disease activity

Motivation: People living with HIV are at increased risk of cardiovascular disease compared with healthy people. Goal(s): To explore the extent of diastolic atrial and left ventricular dysfunction in PLWH by CMR in correlation with clinical markers of disease activity. Approach: 101 PLWH and 62 healthy volunteers were recruited for this study in China. Both left atrial (LA) and LV strain and strain rate were calculated using CMR feature tracking. Results: PLWH had a larger LAVImax, LAVImin and LAVIpre-a as compared to healthy volunteers. The LA reservoir, conduit and booster pump function were all impaired in PLWH. Impact: The prevalence of diastolic dysfunction as well as asymptomatic systolicabnormalities is observed in HIV patients.