Cross-sectional multiparametric subtyping of multiple sclerosis lesions informs on their longitudinal evolution
Motivation: In multiple sclerosis, slowly expanding lesions have been suggested as a hallmark of a steadily worsening disease course. However, identifying these lesions is challenging, as their growth rates are at the detection limit of today's processing algorithms or MRI data must be available over a long period of time. Goal(s): To identify and characterise slowly expanding lesions in cross-sectional data. Approach: We compared changes in quantitative T1, T2 and T2/T1-ratio inside lesions and in perilesional tissue for enlarging/stable/shrinking/new lesion phenotypes. Results: Z-scores of multiparametric quantitative maps carry discriminative information to classify lesion evolution from single time point data. Impact: Our findings suggest that quantitative multiparametric analyses allow a better in vivo characterisation of microstructural tissue pathology in multiple sclerosis; this furthers the understanding of different lesion evolutions and might enable to already distinguish them from cross-sectional data.
Authors
- Veronica Ravano (ORCID: https://orcid.org/0000-0002-1532-9664)
- Tom Hilbert (ORCID: https://orcid.org/0000-0001-8207-4908)
- Dana Horáková (ORCID: https://orcid.org/0000-0003-1915-0036)
- Tomáš Uher (ORCID: https://orcid.org/0000-0003-3160-9022)
- Ricardo Corredor‐Jerez (ORCID: https://orcid.org/0000-0002-8172-9850)
- Jonathan A. Disselhorst (ORCID: https://orcid.org/0000-0002-2924-1866)
- Jonas Richiardi (ORCID: https://orcid.org/0000-0002-6975-5634)
- Michaela Andělová (ORCID: https://orcid.org/0000-0002-3812-7483)
- Bénédicte Maréchal (ORCID: https://orcid.org/0000-0001-7866-2854)
- Gian Franco Piredda (ORCID: https://orcid.org/0000-0002-8449-6634)
- Samuele Caneschi
- Stefan Sommer (ORCID: https://orcid.org/0000-0003-3484-1679)
- Jean‐Philippe Thiran (ORCID: https://orcid.org/0000-0003-2938-9657)
- Tobias Kober (ORCID: https://orcid.org/0000-0001-7598-9456)
- Matej Kudrna (ORCID: https://orcid.org/0009-0000-6694-5929)
- Manuela Vaněčková (ORCID: https://orcid.org/0000-0001-6895-3738)
- Lucia Roccaro
- Jan Krasenky
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2964
- Primary Topic
- Gene expression and cancer classification
- Type
- article
- Field-Weighted Citation Impact
- 0.00