Assessment of early anthracycline-induced cardiotoxicity and liver injury with T2 and T2* mapping in rabbit models

Motivation: Chemotherapy-related cardiotoxicity has garnered more attention, an early assessment of cardiac injury to delay or prevent the occurrence and development of irreversible cardiac injury is vitally important. Goal(s): T2 mapping and T2* mapping are expected to be used for evaluating early anthracycline-induced cardiotoxicity (AIC) and anthracycline-induced liver injury (AILI). Approach: We established a rabbit model of anthracycline-induced cardiotoxicity and dynamically observed the occurrence and progression of AIC and AILI using T2 and T2* mapping. Results: Preliminary results show T2 and T2* mapping showed value one-stop assessment of AIC and AILI. Impact: Anthracycline-induced cardiotoxicity could be detected by T2 mapping as earlier as the second week, mainly focusing on the 7th, 11th and 12th segments of left ventricle. Combined with T2* mapping, hepatoxicity and supplementary cardiotoxicity were assessed by one-stop scan.