Benchmarking a clinical analysis software tool for SAGE based DSC MRI

Motivation: To benchmark multi-echo based DSC-MRI SAGE sequence, a compelling alternative to single echo acquisition analysis tool that is targeted for clinical translation. Goal(s): Comparison of rCBV values derived from the two software (IB Neuro X2, in-house algorithm). Approach: We expanded a single-echo DSC-MRI brain tumor digital reference object (DRO) into an anthropomorphic phantom that recapitulates clinical DSC-MRI data structure and anatomy. Results: The rCBV values obtained from both softwares are strongly correlated. Impact: This study would potentially deliver a robust and reproducible post-processing tool for multi-site, multi-vendor SAGE-based DSC-MRI that can be used for clinical trials.