Multi-Center and Multi-Vendor Platform DCE-MRI Prediction of Breast Cancer Therapy Response: A Preliminary Comparison of Imaging Biomarkers
Motivation: Validate Shutter-Speed model (SSM) DCE-MRI as a robust predictor of breast cancer (BC) response to neoadjuvant chemotherapy (NAC) in a multi-center and multi-vendor platform setting. Goal(s): Compare tumor size, semi-quantitative, and quantitative DCE-MRI for early prediction of NAC response. Approach: BC patients treated with NAC underwent longitudinal high spatiotemporal resolution DCE-MRI at three sites using a 3T Siemens, GE, or Philips system. Semi-quantitative signal-enhancement-ratio (SER) and quantitative Tofts model (TM) and SSM pharmacokinetic (PK) parameters were derived from DCE time-course data. Results: PK parameters outperformed size and SER while SSM was superior to TM in early prediction of pathologic response. Impact: It is feasible to implement quantitative high spatiotemporal resolution SSM DCE-MRI in trials with multi-center and multi-vendor platform settings for robust assessment of BC response to NAC.
Authors
- Evthokia Hobbs (ORCID: https://orcid.org/0000-0002-7738-0131)
- Debosmita Biswas (ORCID: https://orcid.org/0000-0002-0798-5637)
- Savannah C. Partridge (ORCID: https://orcid.org/0000-0001-6370-9111)
- Su Kim (ORCID: https://orcid.org/0000-0002-2645-2844)
- Jennifer M. Specht (ORCID: https://orcid.org/0000-0003-1484-2113)
- Suzanne M. Dintzis (ORCID: https://orcid.org/0000-0001-9762-030X)
- Anum S. Kazerouni (ORCID: https://orcid.org/0000-0002-4200-534X)
- Michael Hirano
- Habib Rahbar (ORCID: https://orcid.org/0000-0003-4835-1478)
- Christian Wille
- Mary Lynn Bryant
- James H. Holmes (ORCID: https://orcid.org/0000-0002-0936-3700)
- Travis Rice‐Stitt
- Chelsea Pyle
- Isabella Li
- Sneha Phadke (ORCID: https://orcid.org/0000-0002-9829-1066)
- Alexandra S. Zimmer (ORCID: https://orcid.org/0000-0001-6789-0982)
- Nicole Margo Grogan Fleege (ORCID: https://orcid.org/0000-0001-9268-7070)
- Amani Bashir (ORCID: https://orcid.org/0000-0002-7239-3662)
- Alina Tudorica
- Assim Saad Eddin (ORCID: https://orcid.org/0009-0000-8769-7311)
- Xin Li (ORCID: https://orcid.org/0000-0002-2949-5663)
- Wei Huang (ORCID: https://orcid.org/0000-0002-3468-7467)
- Brendan Moloney
- Jeong Youn Lim
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4824
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00