DCE-MRI Derived Water Exchange Rate Constant in Multi-Center and Multi-Platform Assessment of Breast Cancer Therapy Response
Motivation: Investigate water exchange rate constant (kio) in monitoring breast cancer (BC) response to neoadjuvant chemotherapy (NAC). Goal(s): Evaluate changes in kio and voxel fraction of filtered kio during NAC. Approach: BC patients treated with NAC underwent longitudinal high spatiotemporal resolution DCE-MRI at three sites using different 3T vendor systems. Voxel kio values were obtained with the shutter-speed modeling and filtered with a biologically relevant and DCE achievable range. Results: Fractions of filtered kio decreased throughout the NAC course. Tumor kio and its heterogeneity were reduced in the pathologic complete response (pCR) group compared to the non-pCR group at midpoint and end of NAC. Impact: Quantitative high spatiotemporal resolution Shutter-Speed Model (SSM) DCE-MRI can be implemented in multi-center and multi-platform settings with the SSM-exclusive kio parameter providing potentially complementary information to the conventional Ktrans parameter in assessment of BC response to NAC.
Authors
- Evthokia Hobbs (ORCID: https://orcid.org/0000-0002-7738-0131)
- Debosmita Biswas (ORCID: https://orcid.org/0000-0002-0798-5637)
- Savannah C. Partridge (ORCID: https://orcid.org/0000-0001-6370-9111)
- Su Kim (ORCID: https://orcid.org/0000-0002-2645-2844)
- Jennifer M. Specht (ORCID: https://orcid.org/0000-0003-1484-2113)
- Suzanne M. Dintzis (ORCID: https://orcid.org/0000-0001-9762-030X)
- X. Allen Li (ORCID: https://orcid.org/0000-0003-2260-0245)
- Anum S. Kazerouni (ORCID: https://orcid.org/0000-0002-4200-534X)
- Michael Hirano
- Habib Rahbar (ORCID: https://orcid.org/0000-0003-4835-1478)
- Wei Huang (ORCID: https://orcid.org/0000-0001-6456-6845)
- James H. Holmes (ORCID: https://orcid.org/0000-0002-0936-3700)
- Travis Rice‐Stitt
- Chelsea Pyle
- Mary Kate Bryant (ORCID: https://orcid.org/0000-0002-2090-1653)
- Isabella Li
- Sneha Phadke (ORCID: https://orcid.org/0000-0002-9829-1066)
- Nicole Margo Grogan Fleege (ORCID: https://orcid.org/0000-0001-9268-7070)
- Amani Bashir (ORCID: https://orcid.org/0000-0002-7239-3662)
- Alina Tudorica
- Assim Saad Eddin (ORCID: https://orcid.org/0009-0000-8769-7311)
- Brendan Moloney
- Alexandra Dos Santos Zimmer
- Courtney Wille
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4622
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00