New Dual-Element 13C/1H Endorectal Coil for Improving mpMR-TRUS Guided Fusion Prostate Biopsies With Hyperpolarized C-13 Molecular Imaging
Motivation: To address the issues with the original dual-element 13C/1H endorectal coil (ERC). Goal(s): We designed and fabricated a novel dual-element 13C/1H ERC, validated with bench testing and then evaluated in 3T MRI studies. Approach: Phantoms were imaged using the new ERC and the original ERC. Acquired data was then analyzed and respective SNR compared. Results: The new ERC demonstrated substantially improved 13C and 1H MRI sensitivity on bench electronic testing. In addition, the new ERC demonstrated substantial improvement in signal-to-noise ratio, and since the coil has successfully been used in hyperpolarized 13C-pyruvate, co-polarized 13C-urea+pyruvate multiparametric MRI patient studies for guiding prostate cancer biopsy. Impact: Hyperpolarized 13C MRI, RF Coils, Metabolic imaging, Molecular imaging, Endorectal coil
Authors
- Kimberly Okamoto
- Mary Frost
- Katsuto Shinohara (ORCID: https://orcid.org/0000-0002-0409-0264)
- Daniel B. Vigneron (ORCID: https://orcid.org/0000-0001-5795-8699)
- Peder E. Z. Larson (ORCID: https://orcid.org/0000-0003-4183-3634)
- Yaewon Kim (ORCID: https://orcid.org/0000-0003-1016-1572)
- Robert Bok (ORCID: https://orcid.org/0000-0003-1737-9056)
- Jeremy W. Gordon (ORCID: https://orcid.org/0000-0003-2760-4886)
- Michael A. Ohliger (ORCID: https://orcid.org/0000-0001-6878-8189)
- Daniel Gebrezgiabhier (ORCID: https://orcid.org/0000-0002-8118-3931)
- Rahul Aggarwal (ORCID: https://orcid.org/0000-0001-7003-7982)
- Matthew R. Cooperberg (ORCID: https://orcid.org/0000-0003-4339-6685)
- Zhen Wang (ORCID: https://orcid.org/0000-0001-5715-2193)
- Hsin-Yu Chen (ORCID: https://orcid.org/0009-0007-9310-4122)
- Hao Nguyen
- Lucas Carvajal
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4751
- Primary Topic
- Enzyme Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00