Multiparametric quantitative MRI for assessment of clinical response to M032 oncolytic virotherapy in patients with high-grade glioma

Motivation: Standard-of-care MRI in high-grade glioma (HGG) immunotherapy offers limited value for early response assessment and monitoring given its inability to distinguish tumor progression from treatment-induced inflammatory responses. Goal(s): This study aims to evaluate multiparametric MRI and voxel-wise habitat mapping of vascular and cellular properties to assess response to M032 virotherapy in HGG. Approach: Multiparametric quantitative assessment of cellularity and vascularity, through DWI-MRI and DSC-MRI, was explored for the early evaluation of intratumoral changes post-immunotherapy and associations with overall survival. Results: Anatomical and quantitative MRI metrics revealed changes early over the course of therapy and showed significant associations with overall survival in this cohort. Impact: Characterization of multiparametric quantitative MRI metrics associated with early immunotherapy positive response can aid in the assessment and monitoring of therapeutic efficacy and allow for optimization of clinical care in patients with high-grade glioma.