Fast Spin Echo based T2 Mapping with Point Spread Function Correction

Motivation: Fast Spin Echo (FSE) based method can provide faster T2 mapping compared to the multi-echo spin echo method. However, the varying Point Spread Functions (PSFs) among different echo time images lead to artifacts in the T2 and proton density ($$$\rho$$$) maps. Goal(s): Developing an algorithm to address PSF artifacts in the FSE-based method that enables faster and more accurate T2 mapping. Approach: An optimization process was designed to determine voxel-wise T2 and $$$\rho$$$ values consistent with the acquired data, especially considering various PSFs. Results: The method was validated through simulations, phantom measurements, and mouse brain scans, resulting in improved T2 and $$$\rho$$$ maps. Impact: The method enabled high-quality, fast T2 mapping without the need for any modifications to the FSE pulse sequence. Therefore, it can be readily applied to quantitative studies on subjects that can be imaged with FSE.