Robust double-diffusion-encoded spectroscopy (DDES) in the human brain on a clinical MR scanner using metabolite-cycling
Motivation: Double-Diffusion-Encoded Spectroscopy (DDES) provides multiple metrics of cell-specific morphology in a single MR experiment but is prone to motion-induced signal distortions. Goal(s): To obtain robust microstructural metrics of cell-type specific diffusion in different brain regions. Approach: We combine DDES with metabolite-cycling (MC) and motion-compensation (MoCom) to correct for signal distortions in post processing. Results: MoCom improves DDES data quality and reproducibility and allows metabolite specific diffusion metrics to be obtained on clinical 3T MR scanners. Impact: The implementation of robust Double-Diffusion-Encoded Spectroscopy (DDES) on clinical MR scanners can shed new light on cellular microstructure in the healthy and pathological brain.
Authors
- Derek Kenton Jones (ORCID: https://orcid.org/0000-0003-4409-8049)
- Nicholas G. Dowell (ORCID: https://orcid.org/0000-0002-1978-4779)
- Henrik Lundell (ORCID: https://orcid.org/0000-0002-7044-442X)
- Matt G. Hall (ORCID: https://orcid.org/0000-0002-9530-5477)
- Chloé Najac (ORCID: https://orcid.org/0000-0002-7804-2281)
- Roland Kreis (ORCID: https://orcid.org/0000-0002-8618-6875)
- Itamar Ronen (ORCID: https://orcid.org/0000-0002-6872-4895)
- Lijing Xin (ORCID: https://orcid.org/0000-0002-5450-6109)
- Jessie Mosso (ORCID: https://orcid.org/0000-0001-6318-9507)
- André Döring (ORCID: https://orcid.org/0000-0002-2096-5374)
Institutions
- Technical University of Denmark (DK)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0645
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00