Frequency-Sensitive MRF (FS-MRF) for improved multi-tissue compartment modelling: a glimpse to tissue frequency from RF frequency

Motivation: Can we encode the tissue's frequency by using RF's frequency?Goal(s): To distinguish tissue components based on their unique frequencies. Approach: Based on 3D MRF technique, we introduced frequency-sensitive module by varying the RF's frequency TR-to-TR. Results: We are able to simultaneously obtain T1, T2 and frequency maps, which help improve the image fedelity and quantitative accuracy. Furthermore, it could provide a tool to differentiate the tissue components based on their frequency. Impact: If one is interested in quantifying tissues with a frequency shift compared to water, such as fat, myelin water and some amino acids, this paper can offer a brand new angle with its noval mechanism.