The relationship of glutamate to glutamine and metabolic profiling in focal epilepsy using 7T CRT-FID-MRSI
Motivation: We want to explore the potential benefits that high-field MRSI can provide added value by allowing for higher spectral resolution of metabolites. Goal(s): Our goal was to test the robustness of 7T-CRT-FID-MRSI in the characterization of epilepsy, in particular with respect to glutamate and glutamine. Approach: We measured 42 patients with focal epilepsy using 7T-CRT-FID-MRSI. The obtained metabolites were normalized to ratios of NAA and tCr and concentration estimates of glutamate and glutamine were related to seizure frequency. Results: We could demonstrate that high-field MRSI shows high sensitivity in identifying epileptic zones as well as a correlation of glutamate/glutamine ratios to seizure frequency. Impact: 7T-CRT-FID MRSI shows high potential for identifying metabolic alterations in epilepsy. Additionally, due to higher spectral resolution, we could demonstrate a correlation of seizure frequency to the glutamate/glutamine ratio, potentially aiding in quantification of seizure burden in clinical practice.
Authors
- Stefanie Chambers (ORCID: https://orcid.org/0009-0006-7463-6636)
- Ekaterina Pataraia (ORCID: https://orcid.org/0000-0002-1454-7600)
- Siegfried Trattnig (ORCID: https://orcid.org/0000-0003-1623-3303)
- Tatjana Traub‐Weidinger (ORCID: https://orcid.org/0000-0003-1118-926X)
- Wolfgang Bogner (ORCID: https://orcid.org/0000-0002-0130-3463)
- Lukas Hingerl (ORCID: https://orcid.org/0000-0003-1808-8349)
- Haniye Shayeste (ORCID: https://orcid.org/0000-0002-9706-7775)
- Lukas Haider (ORCID: https://orcid.org/0000-0002-1556-1770)
- Gregor J. Kasprian (ORCID: https://orcid.org/0000-0003-3858-3347)
- Matthias Tomschik (ORCID: https://orcid.org/0000-0002-6243-1178)
- Gilbert Hangel (ORCID: https://orcid.org/0000-0002-3986-3159)
- Bernhard Strasser (ORCID: https://orcid.org/0000-0001-9542-3855)
- Christian Dorfer (ORCID: https://orcid.org/0000-0002-1843-7732)
- Johannes Koren (ORCID: https://orcid.org/0000-0002-5290-2837)
- Martha Feucht (ORCID: https://orcid.org/0000-0001-7691-8158)
- Jonathan Wais
- Philipp Lazen (ORCID: https://orcid.org/0000-0002-9952-3084)
- Katharina Moser
- Karl Rössler (ORCID: https://orcid.org/0000-0002-9249-8082)
- Florian Mayer (ORCID: https://orcid.org/0009-0007-1271-3314)
- Christoph Baumgartner
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3219
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00