Role of Gd-EOB-DTPA-enhanced MRI in Hepatic Fibrosis Staging: Insights from Hepatobiliary Phase Imaging

Motivation: Noninvasive assessment of hepatic fibrosis progression in individual patients. Goal(s): To explore the value of signal intensity ratio (SIR) and radiomics analysis based on hepatobiliary phase (HBP) of Gd-EOB-DTPA-enhanced MRI in evaluating hepatic fibrosis staging. Approach: The liver–muscle contrast ratio (LMCR) and liver–spleen contrast ratio (LSCR) were measured in HBP image, and the radiomics model and SIR–radiomics combined model were established. Finally, the diagnostic accuracy of SIR and both models in hepatic fibrosis staging were evaluated. Results: The radiomics model exhibited higher diagnostic efficacy than SIR. The SIR–radiomics combined model demonstrated superior diagnostic performance in evaluating hepatic fibrosis staging . Impact: This study constructed a noninvasive hepatic fibrosis diagnostic model using accessible routine sequence and improved the diagnostic efficiency. It offers a reliable approach for early diagnosis and treatment assessment, potentially reducing the need for unnecessary invasive biopsies in the future.